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Invitrogen™ Hemoglobin Chimeric Recombinant Rabbit Monoclonal Antibody (2A1)
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Código de producto. 17921001
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Cantidad:
200 μg
Tamaño de la unidad:
200 microgramos
Código de producto. Cantidad unitSize
17921001 200 μg 200 microgramos
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Código de producto. 17921001

Marca: Invitrogen™ MA548118

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Descripción

Rabbit Recombinant Monoclonal Antibody

Specificity: 2A1 exhibited polyreactive recognition of peptide 100-119 from the alpha subunit and peptide 100-119 frmo the beta subunit. Moreover, 2A1 bound Hb and the Hb-haptoglobin complex with equal efficiency, implying different binding sites on Hb for haptoglobin and 2A1. 2A1 was also found to distinguish between Hb and metHb. Preparation: Murine hybridomas were generated using spleen cells from aging (8-10 month old) NZB/W F1 animals. Hybridomas secreting antibodies reactive to murine hemoglobin were subcloned by limiting dilution and antibody isotypes determined using commercial reagents. Eight-week-old NZB/W F1 were immunized subcutaneously with 50 mg mHb antigen emulsified in Complete Fruends Adjuvant.

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
TRUSTED_SUSTAINABILITY

Spezifikation

Antígeno Hemoglobin Chimeric
Aplicaciones ELISA, Western Blot, Immunocytochemistry
Clasificación Recombinant Monoclonal
Clon 2A1
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.02% ProClin 300
génica HBB
N.º de referencia del gen P01942
Alias de gen alpha one globin; alpha-1 globin; alpha-1-globin; alpha-2 globin chain; Alpha-globin; ALPHA-GLOBIN GENE; delta globin; Haemoglobin; Hb; HBA1; HbA1c; HBA2; HBA-T3; HBH; hemoglobin alpha 1 globin chain; Hemoglobin alpha chain; Hemoglobin subunit alpha; hemoglobin subunit alpha 1; hemoglobin, alpha 1
Símbolos de los genes HBA, HBB
Especie del huésped Rabbit
Inmunógeno Murine hybridomas were generated using spleen cells from aging (8-10 month old) NZB/W F1 animals.
Método de purificación Protein A
Cantidad 200 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 15121, 15127
Especies diana Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG κ
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