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Invitrogen™ HEF1 Monoclonal Antibody (2G9)
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Código de producto. 11544363
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Cantidad:
50 μL
100 μL
Tamaño de la unidad:
100 microlitros
50 microlitros
Código de producto. Cantidad unitSize
11544363 100 μL 100 microlitros
11534363 50 μL 50 microlitros
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Código de producto. 11544363

Marca: Invitrogen™ MA15785

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Descripción

Mouse Monoclonal Antibody

This antibody detects HEF1 in human, mouse, and rat samples. This antibody does not recognize p130cas. It has not been tested on Sin1. This antibody mostly detects HEF1 localized at the focal adhesion sites.

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno HEF1
Aplicaciones Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
Clasificación Monoclonal
Clon 2G9
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.1% sodium azide
génica NEDD9
N.º de referencia del gen O35177, Q14511
Alias de gen Cas scaffolding protein family member 2; CAS2; CASL; CAS-L; cas-like docking; CASS2; Crk-associated substrate lymphocyte-specific protein; Crk-associated substrate related protein Cas-L; CRK-associated substrate-related protein; dJ49G10.2; dJ761I2.1; Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF1; mEF1; Nedd9; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; neural precursor cell expressed, developmentally down-regulated gene 9; p105; p130Cas-related protein; renal carcinoma antigen NY-REN-12
Símbolos de los genes NEDD9
Especie del huésped Mouse
Inmunógeno Fusion protein, corresponding to amino acids 82-398 of Human HEF1.
Método de purificación Protein G
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 18003, 291044, 4739
Especies diana Human, Mouse, Rat
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1 κ
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