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Invitrogen™ HCN1 Monoclonal Antibody (S70), FITC

Código de producto. 17885962
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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17885962 100 μg 100 microgramos
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Código de producto. 17885962 Proveedor Invitrogen™ N.º de proveedor MA545400

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Mouse Monoclonal Antibody

1 μg/mL of MA5-45400 was sufficient for detection of HCN1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 100kDa. No cross-reactivity against HCN2.

HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno HCN1
Aplicaciones Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
Clasificación Monoclonal
Clon S70
Concentración 1 mg/mL
Conjugado FITC
Formulación PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
génica HCN1
N.º de referencia del gen O60741, O88704, Q9JKB0
Alias de gen Bcng1; BCNG-1; Brain cyclic nucleotide-gated channel 1; C630013B14Rik; EIEE24; Hac2; HAC-2; Hcn1; hyperpolarization activated cyclic nucleotide gated potassium channel 1; hyperpolarization-activated cation channel 2; hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; hyperpolarization-activated, cyclic nucleotide-gated K+ 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Símbolos de los genes HCN1
Especie del huésped Mouse
Inmunógeno Fusion protein amino acids 778-910 (C terminus) of rat HCN1.
Método de purificación Protein G
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 15165, 348980, 84390
Especies diana Human, Mouse, Rat
Contenido y almacenamiento 4°C, store in dark
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1
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