Invitrogen™ GPR68 Polyclonal Antibody

Descripción

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat (100%); Mouse, Bat, Dog, Hamster, Panda, Horse, Pig (94%); Bovine, Rabbit, Platypus (89%); Elephant (83%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.