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Invitrogen™ GIMAP8 Polyclonal Antibody
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Product Code. 15711581 Shop All Thermo Scientific Products
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Cantidad:
100 μL
Unit Size:
100 microlitros
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15711581 100 μL 100 microlitros
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Product Code. 15711581 Supplier Invitrogen™ Supplier No. PA553641

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SWVLRERKVV VIDTPDLFSS IACAEDKQRN IQHCLELSAP SLHALLLVIA IGHFTREDEE TAKGIQQVFG AEARRHIIIV FTRKDDLGDD LLQDFIEKNK PLKQLVQDYE GRYCIFNNKT NSKDEQITQV LELLRKVESL VNT Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 48%.

The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
TRUSTED_SUSTAINABILITY

Specifications

Antígeno GIMAP8
Aplicaciones Immunohistochemistry (Paraffin), Western Blot
Clasificación Polyclonal
Concentración 0.05 mg/mL
Conjugado Unconjugated
Formulación PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
génica GIMAP8
N.º de referencia del gen Q8ND71
Alias de gen GIMAP8; Gm457; GTPase IMAP family member 8; GTPase, IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN6; IAN9; IAN-9; Iant; IMAP8; Immune-associated nucleotide-binding protein 9; immunity-associated protein 8; mGIMAP8; Protein IanT
Símbolos de los genes GIMAP8
Especie del huésped Rabbit
Inmunógeno Recombinant protein corresponding to Human GIMAP8. Recombinant protein control fragment (Product #RP-90834).
Método de purificación Antigen affinity chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 155038
Especies diana Human
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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