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FLT3 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Marca:  Invitrogen PA128018

Detalles adicionales : Peso : 0.01000kg

Código de producto. 11531343

  • 451.00€ / 25 microgramos
Fecha estimada de envío: 15-03-2024
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Descripción

Descripción

PA1-28018 detects FLT3 from human samples. PA1-28018 has been successfully used in ELISA, Western blot applications. The PA1-28018 immunogen is: Purified recombit human Flt3 extracellular domain, expressed in mouse NSO cells. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Especificaciones

Especificaciones

FLT3
Polyclonal
Unconjugated
P36888
FLT3
Purified recombit human Flt3 extracellular domain, expressed in mouse NSO cells.
25 μg
Primary
Human
Antibody
IgG
ELISA, Western Blot
0.1 mg/mL
FLT3
RP11-153M24.3, CD135, FLK2, STK1
Goat
Antigen affinity chromatography
RUO
2322
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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