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Invitrogen™ FAM193B Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA584365
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Descripción
Immunogen sequence: NTVPNLSRVI WVKTPKPGYP SSEEPSSKEV PSCKQELPEP VSSGGKPQKG KRQGSQAKKS EASPAPRPPA SLEVPSAKGQ VAGPKQ Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 79%.
FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.
Especificaciones
| FAM193B | |
| Polyclonal | |
| Unconjugated | |
| FAM193B | |
| FAM193B; family with sequence similarity 193 member B; IRIZIO; KIAA1931; Protein FAM193B | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 54540 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q96PV7 | |
| FAM193B | |
| Recombinant protein fragment of Human FAM193B (Product #RP-106816) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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