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Invitrogen™ EGFR Recombinant Rabbit Monoclonal Antibody (30H45L48), Alexa Fluor™ 488
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Código de producto. 15947264
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Cantidad:
50 μL
Tamaño de la unidad:
50 microlitros
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15947264 50 μL 50 microlitros
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Código de producto. 15947264 Proveedor Invitrogen™ N.º de proveedor MA700308A488

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Descripción

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with canine, mouse and rat based on sequence homology. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno EGFR
Aplicaciones Immunocytochemistry
Clasificación Recombinant Monoclonal
Clon 30H45L48
Concentración 1 mg/mL
Conjugado Alexa Fluor 488
Formulación PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
génica EGFR
N.º de referencia del gen P00533
Alias de gen 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Símbolos de los genes EGFR
Especie del huésped Rabbit
Inmunógeno Proprietary.
Método de purificación Protein A
Cantidad 50 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 1956
Especies diana Human
Contenido y almacenamiento 4°C, store in dark, DO NOT FREEZE!
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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