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  5. Tocris Bioscience™ EED 226

Tocris Bioscience™ EED 226
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Código de producto. 18719266
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Cantidad:
10 mg
50 mg
Unit Size:
10 miligramos
50 miligramos
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Product Code. 18719266

Brand: Tocris Bioscience™ 7762/50

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Description

Potent and selective EED inhibitor

EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Nombre del producto químico o material N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS 2083627-02-3
Cantidad 50 mg
Objetivo EED
Fórmula molecular C17H15N5O3S
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