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Invitrogen™ EEA1 Polyclonal Antibody
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Código de producto. 11541472
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
11541472 100 μg 100 microgramos
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Código de producto. 11541472

Marca: Invitrogen™ PA1063A

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Descripción

Rabbit Polyclonal Antibody

PA1-063A detects early endosomal antigen 1 (EEA1) from mouse and human samples. Previous lots of this antibody have been used on hamster, canine, and rat samples. PA1-063A has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~160 kDa protein representing EEA1 from mouse brain extract. Previous lots of this antibody have been used in immunoprecipitation and immunofluorescence procedures. The PA1-063A immunogen is a synthetic peptide corresponding to residues T(1391) P S S K K P V R V C D A C F N D L Q G(1410) of human EEA1. The PA1-063A immunizing peptide (Cat. # PEP-079) is available for use in neutralization and control experiments.

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
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Especificaciones

Antígeno EEA1
Aplicaciones Western Blot, Immunocytochemistry
Clasificación Polyclonal
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 1mg/mL BSA and 0.05% sodium azide
génica EEA1
N.º de referencia del gen Q15075, Q8BL66
Alias de gen A430109M19Rik; B230358H09Rik; Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Símbolos de los genes EEA1
Especie del huésped Rabbit
Inmunógeno Synthetic peptide corresponding to residues T(1391) P S S K K P V R V C D A C F N D L Q G(1410) of human EEA1.
Método de purificación Antigen affinity chromatography
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 216238, 8411
Especies diana Human, Mouse
Contenido y almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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