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CYFIP1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 16011-1-AP-20UL
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Descripción
This antibody can recognize both CYFIP1 and CYFIP2.
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.Especificaciones
| CYFIP1/2 | |
| Polyclonal | |
| Unconjugated | |
| CYFIP1 | |
| CYFIP2, KIAA1168, p53 inducible protein 121, PIR121 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 20430, 23191, 26999, 76884 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation | |
| 0.19 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q5SQX6, Q7L576, Q7TMB8, Q96F07 | |
| Cyfip1, Cyfip2 | |
| CYFIP1/2 Fusion Protein Ag8749 | |
| 20 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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