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Invitrogen™ CDK7 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA517128
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Descripción
It is not recommended to aliquot this antibody.
The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.
Especificaciones
| CDK7 | |
| Polyclonal | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| P50613, P51952, Q03147 | |
| CDK7 | |
| Synthetic peptide corresponding to the amino terminus of human CDK7. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Monkey | |
| Antibody | |
| IgG |
| Western Blot | |
| Unconjugated | |
| CDK7 | |
| 39 KDa protein kinase; 39 protein kinase; AI323415; AI528512; C230069N13; CAK; CAK1; CDK; CDK7; CDK-activating kinase; CDK-activating kinase 1; Cdkn7; cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); cyclin dependent kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; HCAK; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; Mpk-7; OTTHUMP00000222032; OTTHUMP00000222033; p39 Mo15; p39MO15; Protein-tyrosine kinase MPK-7; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; STK1; TFIIH basal transcription factor complex kinase subunit | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 1022, 12572, 171150 | |
| -20°C | |
| Liquid |
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