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CD73 Mouse, anti-Human, APC, Clone: AD2, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60044AZ.1
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Descripción
- The AD2 antibody reacts with human CD73, a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein and ecto-5'-nucleotidase expressed on the surface of subsets of B and T cells, follicular dendritic cells, mesenchymal stem cells, endothelial cells, and epithelial cells
- CD73 catalyzes the hydrolysis of 5'-adenosine monophosphate (AMP) to form the bioactive nucleoside adenosine, and plays a pivotal role in the activation of P1 adenosine receptors by regulating extracellular adenosine concentrations
- CD73 also appears to function as a co-signaling molecule on T cells and as an adhesion molecule mediating lymphocyte interactions with the endothelium and follicular dendritic cells
- CD73 is used as a marker for lymphocyte differentiation, its expression increasing during development
- It is also a useful marker for identifying undifferentiated mesenchymal stem cells
- CD73 is highly expressed in many types of human and mouse cancers, and has been implicated in the control of tumor growth
Especificaciones
| CD73 | |
| Monoclonal | |
| APC | |
| 25 Tests | |
| Rhesus Monkey, Chimpanzee, Human, Macaque | |
| Mesenchymal Stem and Progenitor Cells |
| Immunohistochemistry, Flow Cytometry, Immunofluorescence | |
| AD2 | |
| Mouse | |
| Primary | |
| IgG1 κ |
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