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Invitrogen™ CD72 Monoclonal Antibody (3F3)

Descripción
This antibody recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes differentiation with the exception of plasma cells; it is also present on follicular dendritic cells.
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
Especificaciones
Especificaciones
| Antígeno | CD72 |
| Aplicaciones | Flow Cytometry, Immunoprecipitation |
| Clasificación | Monoclonal |
| Clon | 3F3 |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 15mM sodium azide; pH 7.4 |
| génica | CD72 |
| N.º de referencia del gen | P21854 |
| Alias de gen | B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9 |
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Título del producto
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