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CD54 (ICAM-1) Rat, anti-Mouse, Unconjugated, Clone: YN1/1.7.4, STEMCELL Technologies
Rat Monoclonal Antibody
Marca: Stemcell Technologies 60151
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Descripción
- The YN1/1.7.4 antibody reacts with CD54, a 90 - 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily
- CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing
- As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events
- CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)
- CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses
- CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules
- Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-γ
Especificaciones
| CD54 (ICAM-1) | |
| Monoclonal | |
| Unconjugated | |
| 500 μg | |
| Mouse | |
| Endothelial Cells |
| Immunoblot, Flow Cytometry, Immunoprecipitation | |
| YN1/1.7.4 | |
| Rat | |
| Primary | |
| IgG2b κ |
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