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CD49f (Integrin α6) Rat, anti-Mouse, APC, Clone: GoH3, STEMCELL Technologies
Rat Monoclonal Antibody
Marca: Stemcell Technologies 60037AZ.1

Descripción
- The GoH3 antibody reacts with CD49f (integrin α6), an ∼150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin
- CD49f is a disulfide-linked dimer comprising an ∼120 kDa heavy chain and an ∼30 kDa membrane-bound light chain
- Splice variants exist, which affect the cytoplasmic domain of the protein
- CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells
- It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency
- CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells
- The GoH3 antibody reacts with an extracellular epitope on CD49f
Especificaciones
CD49f (Integrin α6) | |
Monoclonal | |
APC | |
25 Tests | |
Baboon, Cynomolgus, Pig, Human | |
Mammary Cells |
Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
GoH3 | |
Rat | |
Primary | |
IgG2a κ |
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