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CD49f (Integrin α6) Rat, anti-Mouse, APC, Clone: GoH3, STEMCELL Technologies
Descripción
- The GoH3 antibody reacts with CD49f (integrin α6), an ∼150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin
- CD49f is a disulfide-linked dimer comprising an ∼120 kDa heavy chain and an ∼30 kDa membrane-bound light chain
- Splice variants exist, which affect the cytoplasmic domain of the protein
- CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells
- It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency
- CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells
- The GoH3 antibody reacts with an extracellular epitope on CD49f
Especificaciones
Especificaciones
| Antígeno | CD49f (Integrin α6) |
| Aplicaciones | Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay |
| Clasificación | Monoclonal |
| Clon | GoH3 |
| Conjugado | APC |
| Especie del huésped | Rat |
| Cantidad | 100 Tests |
| Primario o secundario | Primary |
| Especies diana | Baboon, Cynomolgus, Pig, Human |
| Isotype | IgG2a κ |
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Título del producto
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