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CD49b (Integrin α2) Rat, anti-Mouse, PE, Clone: DX5, STEMCELL Technologies
Descripción
- The DX5 antibody reacts with murine CD49b (integrin α2), an ∼150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) to form the heterodimeric CD49b/CD29 complex known as VLA-2, a receptor for extracellular matrix proteins such as collagen, E-cadherin, fibronectin, and laminin
- CD49b is highly expressed by platelets and is found on a majority of NK cells, on NKT cells, and on a small subset of CD8+ T cells; the latter population increases substantially following viral infection
- CD49b is also expressed by several tissues, including intestine, kidney, mammary gland, and lung
- Binding of the DX5 antibody has not been observed to affect the function of the VLA-2 integrin
- DX5 binding is, however, blocked by the clone HMα2 antibody
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ Mouse NK Cell Enrichment Kit (Catalog #19755)
Especificaciones
Especificaciones
| Antígeno | CD49b (Integrin α2) |
| Aplicaciones | Immunohistochemistry, Flow Cytometry |
| Clasificación | Monoclonal |
| Clon | DX5 |
| Conjugado | PE |
| Especie del huésped | Rat |
| Cantidad | 50 μg |
| Primario o secundario | Primary |
| Especies diana | Mouse |
| Isotype | IgM κ |
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Título del producto
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