Invitrogen™ CD49a (Integrin alpha 1) Recombinant Rabbit Monoclonal Antibody (7T5B6)

Descripción

Immunogen Sequence: FNVDVKNSMT FSGPVEDMFG YTVQQYENEE GKWVLIGSPL VGQPKNRTGD VYKCPVGRGE SLPCVKLDLP VNTSIPNVTE VKENMTFGST LVTNPNGGFL ACGPLYAYRC GHLHYTTGIC SDVSPTFQVV NSIAPVQECS TQLDIVIVLD GSNSIYPWDS VTAFLNDLLE RMDIGPKQTQ VGIVQYGENV THEFNLNKYS STEEVLVAAK KIVQRGGRQT MTALGIDTAR KEAFTEARGA RRGVKKVMVI VTDGESHDNH RLKKVIQDCE DENIQRFSIA ILGSYNRGNL STEKFVEEIK SIASEPTEKH FFNVSDELAL VTIVKTLGER IFALEATADQ SAASFEMEMS QTGFSAHYSQ DWVMLGAVGA YDWNGTVVMQ KASQIIIPRN TTFNVESTKK NEPLASYLGY TVNSATASSG DVLYIAGQPR YNHTGQVIIY RMEDGNIKIL QTLSGEQIGS YFGSILTTTD IDKDSNTDIL LVGAPMYMGT EKEEQGKVYV YALNQTRFEY QMSLEPIKQT CCSSRQHNSC TTENKNEPCG ARFGTAIAAV KDLNLDGFND IVIGAPLEDD HGGAVYIYHG SGKTIRKEYA QRIPSGGDGK TLKFFGQSIH GEMDLNGDGL TDVTIGGLGG AALFWSRDVA VVKVTMNFEP NKVNIQKKNC HMEGKETVCI NATVCFDVKL KSKEDTIYEA DLQYRVTLDS LRQISRSFFS GTQERKVQRN ITVRKSECTK HSFYMLDKHD FQDSVRITLD FNLTDPENGP VLDDSLPNSV HEYIPFAKDC GNKEKCISDL SLHVATTEKD LLIVRSQNDK FNVSLTVKNT KDSAYNTRTI VHYSPNLVFS GIEAIQKDSC ESNHNITCKV GYPFLRRGEM VTFKILFQFN TSYLMENVTI YLSATSDSEE PPETLSDNVV NISIPVKYEV GLQFYSSASE YHISIAANET VPEVINSTED IGNEINIFYL IRKSGSFPMP ELKLSISFPN MTSNGYPVLY PTGLSSSENA NCRPHIFEDP FSINSGKKMT TSTDHLKRGT ILDCNTCKFA TITCNLTSSD ISQVNVSLIL WKPTFIKSYF SSLNLTIRGE LRSENASLVL SSSNQKRELA IQISKDGLPG RVP.

Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.