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CD48 (SLAMF2) Hamster, anti-Mouse, APC, Clone: HM48-1, STEMCELL Technologies
Descripción
- The HM48-1 antibody reacts with mouse CD48, a 45 kDa GPI-anchored glycoprotein and a member of the signaling lymphocyte activation molecule (SLAM) family and Ig superfamily
- SLAM family members play a role in multiple aspects of immune function including costimulation, cytotoxicity, and cytokine production
- CD48 also plays a role in cell adhesion and T cell activation
- In mice, CD48 is thought to be present on nearly all hematopoietic cells except neutrophils and ESLAM cells (CD45+EPCR+CD48-CD150+ hematopoietic stem cells with long-term self-renewal capacity)
- Ligands for CD48 include CD2 and CD244, binding of which helps to promote interactions between immune cells
- HM48-1 is reported to be capable of blocking CD48:CD2 and CD48:CD244 interactions in vitro and in vivo
- HM48-1 is also reported to inhibit the proliferative response of spleen cells to mitogens, inhibit CTL activity, and enhance the survival of cardiac allografts
Especificaciones
Especificaciones
| Antígeno | CD48 (SLAMF2) |
| Aplicaciones | Flow Cytometry |
| Clasificación | Monoclonal |
| Clon | HM48-1 |
| Conjugado | APC |
| Especie del huésped | Hamster |
| Cantidad | 25 μg |
| Primario o secundario | Primary |
| Especies diana | Mouse |
| Isotype | IgG1 λ3 |
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Título del producto
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