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Invitrogen™ CD45RO Monoclonal Antibody (UCHL1)
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Código de producto. 11564672
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
11564672 100 μg 100 microgramos
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Código de producto. 11564672

Marca: Invitrogen™ MA119452

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Descripción

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes. Pretreatment note: MA1-19452 does not require protein digestion pretreatment of paraffin sections and does not require antigen retrieval using heat treatment prior to staining of paraffin sections. A suggested positive control for this product is tonsil tissue.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno CD45RO
Aplicaciones Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clasificación Monoclonal
Clon UCHL1
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 15mM sodium azide; pH 7.4
génica PTPRC
N.º de referencia del gen P08575
Alias de gen B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
Símbolos de los genes PTPRC
Especie del huésped Mouse
Inmunógeno Human IL-2 dependent T cells.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 5788
Especies diana Human
Contenido y almacenamiento 4°C, do not freeze
Tipo de producto Antibody
Formulario Liquid
Isotype IgG2a
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