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CD4 Rat, anti-Mouse, APC, Clone: RM4-4, STEMCELL Technologies
Rat Monoclonal Antibody
Marca: Stemcell Technologies 60029AZ
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Descripción
- The RM4-4 antibody reacts with mouse CD4, an ∼55 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobin (Ig) superfamily; CD4 contains four extracellular Ig-like domains
- CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper/inducer cells), and at lower levels on dendritic cells
- In the mouse, CD4 is not expressed by monocytes/macrophages
- CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the avidity of the association between the TCR and MHC II-antigen complex
- CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck
- Binding of the RM4-4 antibody does not block binding of antibody clones RM4-5 or GK1.5
Especificaciones
| CD4 | |
| Monoclonal | |
| APC | |
| 100 μg | |
| Mouse | |
| T Cells, T Cells, CD4+, T Cells, Regulatory |
| Flow Cytometry, Functional Assay | |
| RM4-4 | |
| Rat | |
| Primary | |
| IgG2b κ |
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