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Invitrogen™ CD31 Monoclonal Antibody (ER-MP12)
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Código de producto. 11529682
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
11529682 100 μg 100 microgramos
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Código de producto. 11529682

Marca: Invitrogen™ MA140074

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Descripción

Rat Monoclonal Antibody

MA1-40074 detects CD31 from mouse samples. MA1-40074 reacts with an antigen present on cell subpopulations of adult mouse bone marrow, including pluripotent hematopoietic stem cells. MA1-40074 reacts with the major population of colony forming unit macrophage (CFU-M) precursor cells, with subpopulation of pre CFU-M and monoblasts, and with precursor cells of granulocytes. MA1-40074 has been successfully used in ELISA, immunohistochemistry (paraffin and frozen), immunoprecipitation, and flow cytometry applications. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting, working dilution is 1:50. The MA1-40074 immunogen is mouse PECAM-1/CD31. Suggested positive control: Macrophage cell line RMB-1.

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
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Especificaciones

Antígeno CD31
Aplicaciones ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clasificación Monoclonal
Clon ER-MP12
Concentración 0.1 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.1% BSA and 0.02% sodium azide
génica Pecam1
N.º de referencia del gen Q08481
Alias de gen C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
Símbolos de los genes Pecam1
Especie del huésped Rat
Inmunógeno Murine macrophage precursor hybrid W1C3cell hybrid.
Método de purificación Protein G
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 18613
Especies diana Mouse
Contenido y almacenamiento 4°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG2a
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