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CD3 Mouse, anti-Human, FITC, Clone: OKT3, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 100-0285
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Descripción
- The OKT3 antibody reacts with an extracellular conformational epitope on the ∼20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ∼95% of mature T cells and NKT cells, and variably on thymocytes
- A majority of T cell neoplasms also express CD3
- CD3 is a dimer assembled from combinations of CD3γ, δ, ε, η, and ζ subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily
- CD3 associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating T cell activation and the expression of the TCR on the cell surface
- Mutations in CD3 have been associated with disorders of the immune system, including severe combined immunodeficiency (SCID)
- The OKT3 antibody recognizes an epitope that is expressed when the CD3ε subunit associates with either CD3γ or CD3δ, and binding of the antibody can induce T cell activation
- Because of its immunosuppressive properties in vivo, the OKT3 antibody has proven useful in treating allograft rejection
- Clone OKT3 is widely used for phenotyping human T cells, and it has been observed to block the binding of anti-CD3 antibody clones SK7 and UCHT1
Especificaciones
| CD3 | |
| Monoclonal | |
| FITC | |
| 25 Tests | |
| Human | |
| T Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay | |
| OKT3 | |
| Mouse | |
| Primary | |
| IgG2a κ |
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