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CD267 Rat anti-Human, Brilliant Violet 421, Clone: 1A1-K21-M22 (also known as 1A1), BD Optibuild™

Código de producto. 15858809
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Cantidad:
50 μg
Tamaño de la unidad:
cada uno
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15858809 50 μg cada uno
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Código de producto. 15858809 Proveedor BD Biosciences N.º de proveedor 744143

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Descripción

Rat Monoclonal Antibody

The 1A1-K21-M22 monoclonal antibody specifically binds to CD267 which is also known as TACI (Transmembrane Activator and CAML Interactor). CD267 is a member of the of the Tumor Necrosis Factor Receptor (TNFR) Superfamily and is encoded by the TNFRSF13B gene. This 32 kDa type III transmembrane protein receptor binds to the ligands, BAFF (TNFSF13B/BLyS/CD257) and APRIL (TNFSF13/CD256). Ligand-bound CD267 transduces signals leading to the activation of transcription factors including NFAT, AP1, and NF-kappa-B. CD267 is expressed most notably on maturing subsets of B cells and myeloma cells. In CD267 deficient mice, B cell numbers are increased and mice develop autoimmune disorders suggesting that CD267 plays an important role in the regulation of B cell homeostasis.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno CD267
Clasificación Monoclonal
Clon 1A1-K21-M22 (also known as 1A1)
Concentración 0.2mg/mL
Conjugado Brilliant Violet 421
Formulación Aqueous buffered solution containing ≤0.09% sodium azide.
Alias de gen TACI, TNFRSF13B, Tumor necrosis factor receptor 13B, TNFRSF14B2, CVID2
Especie del huésped Rat
Inmunógeno Human TACI-transfected RBL cells
Método de purificación Affinity Purified
Cantidad 50 μg
Estado normativo RUO
Primario o secundario Primary
Especies diana Human
Contenido y almacenamiento Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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