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CD184 (CXCR4) Mouse, anti-Human, PE, Clone: 12G5, STEMCELL Technologies
Descripción
- The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ∼45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons
- At least two isoforms of CD184 are generated by alternate mRNA splicing
- Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin
- CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance
- CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody
- The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx
- CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm
Especificaciones
Especificaciones
| Antígeno | CD184 (CXCR4) |
| Aplicaciones | CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay |
| Clasificación | Monoclonal |
| Clon | 12G5 |
| Conjugado | PE |
| Especie del huésped | Mouse |
| Cantidad | 100 Tests |
| Primario o secundario | Primary |
| Especies diana | African Green Monkey, Baboon, Cynomolgus, Rhesus Monkey, Human |
| Isotype | IgG2a κ |
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Título del producto
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