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Invitrogen™ CD138 Polyclonal Antibody
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Código de producto. 10788003
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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Código de producto. Cantidad unitSize
10788003 100 μg 100 microgramos
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Código de producto. 10788003 Proveedor Invitrogen™ N.º de proveedor 362900

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Descripción

Rabbit Polyclonal Antibody

This antibody reacts with the human Syndecan-1 (CD38) protein. On western blots, a single band at ~90 kDa representing the glycosylated form of CD138; occasionally a band of ~31 kDa representing the un-glycosylated form of CD138 may be observed. Reactivity has been confirmed with human T47D, SW-480, and PC-3 cell lysates by western blotting and with formalin-fixed, paraffin-embedded (FFPE) human gastric cancer and breast cancer tissues, and mouse and rat stomach, small bowel, and skin tissues by immunohistochemistry. For best results in immunohistochemistry with formalin-fixed, paraffin-embedded (FFPE) tissues, heat induced epitope retrieval (HIER) with EDTA, pH 8.0, is required prior to staining.

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
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Especificaciones

Antígeno CD138
Aplicaciones ELISA, Immunohistochemistry (Paraffin), Western Blot
Clasificación Polyclonal
Concentración 0.25 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.1% sodium azide; pH 7.4
génica Sdc1
N.º de referencia del gen P18827, P18828, P26260
Alias de gen AA408134; AA409076; CD antigen 138; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; HSPG; sCD138; SDC; Sdc1; soluble CD138; Sstn; syn-1; Synd; SYND1; Synd-1; SYNDECA; syndecan; syndecan 1; syndecan proteoglycan 1; Syndecan1; syndecan-1; synstatin
Símbolos de los genes Sdc1
Especie del huésped Rabbit
Inmunógeno Synthetic peptide derived from an internal region of the human Syndecan-1 protein.
Método de purificación Antigen affinity chromatography
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 20969, 25216, 6382
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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