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Invitrogen™ CD137 Polyclonal Antibody
Goat Polyclonal Antibody
Marca: Invitrogen™ PA547037
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Descripción
In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse (rm) 4-1BB, recombinant human (rh) NGF R, rhTNF RI and rhTNF RII is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Especificaciones
| CD137 | |
| Polyclonal | |
| Unconjugated | |
| TNFRSF9 | |
| 4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 3604 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
| ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.2 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| Q07011 | |
| TNFRSF9 | |
| Mouse myeloma cell line NS0-derived recombinant human 4-1BB/TNFRSF9/CD137 Leu24-Gln186. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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