Invitrogen™ CaMKIV Recombinant Rabbit Monoclonal Antibody (1G4P4)

Descripción

Positive test controls include: SH-SY5Y, Mouse thymus. Immunogen sequence: EGEKIQGDGA QAAVKGAQAE LMKVQALEKV KGADINAEEA PKMVPKAVED GIKVADLELE EGLAEEKLKT VEEAAAPREG QGSSAVGFEV PQQDVILPEY.

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.