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Invitrogen™ BRAP Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA559145
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Descripción
Immunogen sequence: SLVVIRLELA EHSPVPAGFG FSAAAGEMSD EEIKKTTLAS AVACLEGKSP GEKVAIIHQH LGRREMTDVI IETMKSNPDE LKTTVEERKS SEA Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Especificaciones
| BRAP | |
| Polyclonal | |
| Unconjugated | |
| BRAP | |
| 3010002G07Rik; BRAP; BRAP2; BRCA1 associated protein; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 687346, 72399, 8315 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q7Z569, Q99MP8 | |
| BRAP | |
| Recombinant protein corresponding to Human BRAP. Recombinant protein control fragment (Product #RP-97663). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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