Invitrogen™ BMP-4 Monoclonal Antibody (10F4B4)

Descripción

MA5-15572 targets BMP4 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15572 immunogen is purified recombinant fragment of human BMP4 expressed in E. Coli. MA5-15572 detects BMP4 which has a predicted molecular weight of approximately 64kDa.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.