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Invitrogen™ beta Synuclein Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA583296
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Descripción
Immunogen sequence: GNIAAATGLV KREEFPTDLK PEEVAQEAAE EPLIEPLMEP EGESYEDPPQ EEYQEYEPEA Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 97%.
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
Especificaciones
| beta Synuclein | |
| Polyclonal | |
| Unconjugated | |
| SNCB | |
| AI838531; betaSYN; beta-synuclein; Phosphoneuroprotein 14; PNP 14; Sncb; synuclein beta; synuclein, beta | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 104069, 6620 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q16143, Q91ZZ3 | |
| SNCB | |
| Recombinant protein corresponding to Human SNCB. Recombinant protein control fragment (Product #RP-96816). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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