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Descripción
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
Especificaciones
Especificaciones
| Antígeno | Beta Arrestin 2 |
| Aplicaciones | Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunocytochemistry |
| Clasificación | Polyclonal |
| Concentración | 0.27 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| génica | ARRB2 |
| N.º de referencia del gen | P32121, Q91YI4 |
| Alias de gen | ARB2, ARR2, ARRB2, Arrestin beta 2, arrestin, beta 2, BARR2, Beta arrestin 2 |
| Símbolos de los genes | ARRB2 |
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Título del producto
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