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Invitrogen™ BARD1 Polyclonal Antibody

Descripción
Keep as concentrated solution. Positive Control: A431, A431 nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Especificaciones
Especificaciones
| Antígeno | BARD1 |
| Aplicaciones | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.58 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 20% glycerol and 0.025% ProClin 300; pH 7 |
| génica | BARD1 |
| N.º de referencia del gen | O70445, Q99728, Q9QZH2 |
| Alias de gen | BARD 1; Bard1; BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; ENSMUSG00000060893; ENSMUSG00000073653; RING-type E3 ubiquitin transferase BARD1 |
| Símbolos de los genes | BARD1 |
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Título del producto
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