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Invitrogen™ BACE2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA529882
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Descripción
Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (88%), Rat (88%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
Especificaciones
| BACE2 | |
| Polyclonal | |
| Unconjugated | |
| BACE2 | |
| 1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 25825, 288227 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.83 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q6IE75, Q9Y5Z0 | |
| BACE2 | |
| Recombinant protein encompassing a sequence within the C-terminus region of human BACE2. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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