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Invitrogen™ ASM Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA595730
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Descripción
Positive Samples: THP-1, HepG2, U-251MG, MCF-7, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Lysosome Immunogen sequence: PARLHRIVPR LRDVFGWGNL TCPICKGLFT AINLGLKKEP NVARVGSVAI KLCNLLKIAP PAVCQSIVHL FEDDMVEVWR RSVLSPSEAC GLLLGSTCGH WDIFSSWNIS LPTVPKPPPK PPSPPAPGAP VSRILFLTDL HWDHDYLEGT DPDCADPLCC RRGSGLPPAS RPGAGYWGEY SKCDLPLRTL ESLLSGLGPA GPFDMVYWTG DIPAHDVWHQ TRQDQLRALT TVTALVRKFL GPVPVYPAVG NHESTPVNSF PPPFIEGNHS S.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Three transcript variants encoding two different isoforms have been found for this gene.
Especificaciones
| ASM | |
| Polyclonal | |
| Unconjugated | |
| Smpd1 | |
| Acid sphingomyelinase; ASM; aSMase; A-SMase; NPD; Smpd1; Sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase 1; sphingomyelin phosphodiesterase 1, acid lysosomal; Zn-SMase | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 20597, 308909, 6609 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 1.34 mg/mL | |
| PBS with 50% glycerol and 0.09% sodium azide; pH 7.3 | |
| P17405, Q04519 | |
| Smpd1 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 70-340 of human SMPD1 / ASM (NP_0005343). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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