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Villin Mouse anti-Human, Unlabeled, Clone: 12, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 610358
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Descripción
The isolated intestinal microvillus cytoskeleton (core) consists of four major proteins: actin, villin, fimbrin, and brush border myosin-I. These proteins can assemble in vitro into structures resembling native microvillus cores. Of these components, villin, and brush border myosin-I show tissue-specific expression, so they may be involved in the morphogenesis of intestinal microvilli. Found in association with the microvillar actin bundles of the intestinal brush border, villin is a 95kDa protein composed of two very similar domains of approximately 44kDa each, the core, and a C-terminal domain of 8kDa, the headpiece. The core has been shown to contain villin's Ca2+ regulated capping, nucleating, and severing activities, but it cannot induce the formation of microfilament bundles without the headpiece. Villin is a useful differentiation marker of early embryogenesis and may be useful in diagnosis and follow-up of colorectal cancers. It has been demonstrated that villin is necessary for both the cytoskeletal and membrane protein organization of a functional brush border.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Especificaciones
| Villin | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| 50 μg | |
| Cell Biology | |
| Human | |
| IgG1 |
| Immunofluorescence, Immunohistochemistry, Western Blot | |
| 12 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
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Título del producto
For Research Use Only.
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