anti-VE-cadherin/CD144 PE, Clone: 16B1, Invitrogen™

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1
Clone: 16B1
Immunogen: Human CD144
Formulation: 25μg Purified Antibody (0.2mg/ml) in proprietary buffer, with 0.09% sodium azide
Synonyms: Cadherin-5, Vascular endothelial cadherin, VE-cadherin, 7B4 antigen, CD144 antigen, CDH5
Uniprot Accession: P33151
Entrez GeneID: 1003
Gene Symbol: CDH5
This product detects VE-cadherin/CD144 in Human samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Human CD144.