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Underphosphorylated Retinoblastoma Mouse anti-Human, Unlabeled, Clone: G99-549, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 554164
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Descripción
The retinoblastoma gene encodes a nuclear phosphoprotein (Rb or p110Rb) which is expressed in most normal cells of vertebrates and acts as a tumor suppressor gene product. An underphosphorylated form of Rb is mainly found in resting or fully differentiated cells, whereas the hyperphosphorylated form is present in proliferating cells. Only the underphosphorylated form of Rb binds specifically to viral oncogenes such as SV40 large T, adenoviral EIA and HPV-E7. This interaction may partially contribute to the transforming activity of these viral oncoproteins. Rb also interacts with several cyclins including A, D, and E as well as the transcriptional activator E2F. The importance of these interactions for the biological function of Rb is still being elucidated. G99-549 recognizes only the fast migrating, underphosphorylated form of Rb protein. G99-549 cross-reacts with mouse underphosphorylated Rb. The epitope has been mapped to amino acids 514-610 (box A) of human Rb. Recombinant full-length human Rb was produced in the baculovirus expression vector system (BEVS), purified and used as immunogen.
Host Species: Mouse
Clone: G99-549
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant full-length human Rb
Formula Weight [Chemical]: 105kDa
Immunoprecipitation, Western Blotting
Especificaciones
| Underphosphorylated Retinoblastoma | |
| Monoclonal | |
| 0.5mg/mL | |
| RB (a.a. 514-610) | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
| Immunoprecipitation | |
| G99-549 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Recombinant full-length human Rb | |
| 0.1 mg | |
| Cell Biology | |
| Human, Mouse | |
| IgG1 |
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For Research Use Only.
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