anti-Transferrin Receptor/CD71 PE, Clone: R17217, Invitrogen™

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
Host Species: Rat
Cross Reactivity: Mouse
Isotype: IgG2a, κ
Clone: R17217
Immunogen: Mouse CD71
Formulation: 50μg Purified Antibody (0.2mg/ml) in proprietary buffer, with 0.09% sodium azide
Synonyms: CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Uniprot Accession: Q62351
Entrez GeneID: 22042
Gene Symbol: Tfrc
This product detects Transferrin Receptor/CD71 in Mouse samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Mouse CD71.