Invitrogen™ Synaptophysin Polyclonal Antibody

Descripción

PA1-1043 detects Synaptophysin in rat, mouse, bovine, and sheep samples. PA1-1043 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a ~33.8 kDa protein representing Synaptophysin in rat, mouse and bovine brain tissue as well as sheep retinas. The PA1-1043 immunogen is a synthetic peptide corresponding to residues G(253) P G G Y G P Q D S Y G P Q G G Y Q P D(272) of rat Synaptophysin. This sequence is conserved in many species including human, mouse and bovine. The PA1-1043 immunizing peptide (Cat. # PEP-279) is available for use in neutralization and control experiments.

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.