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SV40 Large T-Antigen Monoclonal Antibody (PAb101 (412)), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA512458
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Descripción
This antibody reacts with native and denatured large T-antigen. It does not react with the small T-antigen of SV40 or the large T-antigen of BKV, human papovavirus.
The SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
Especificaciones
| SV40 Large T-Antigen | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 | |
| Mouse | |
| Protein A | |
| RUO | |
| Virus | |
| Antibody | |
| IgG2a |
| Immunocytochemistry, Immunoprecipitation, Western Blot | |
| PAb101 (412) | |
| Unconjugated | |
| simian vacuolating virus 40; simian virus; Simian virus 40; sv40 large t antigen; sv40 virus large t antigen | |
| SV40 transformed mouse line B4 | |
| 500 μL | |
| Primary | |
| 4° C | |
| Liquid |
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