GPR91, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

SUCNR1 is a 330 amino acid containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication. SUCNR1 a receptor for the citric acid cycle intermediate succinate, functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors including VEGF and may be involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases such as diabetic retinopathy that stem from aberrant neovascularization in the mature retina. Expression of SUCNR1 is common in kidney and in some other tissues.