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RIP2 Mouse anti-Human, Mouse, Rat, Clone: AF28D3, Invitrogen™
Descripción
A suggested positive control for this product is HeLa, 293T, L929 or C6.
The RIP (receptor-interacting protein) family of serine/Threonine kinases (RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors (NF-kB and AP-1) and death-inducing programs. RIP2 (also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-kB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-kB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK.
Especificaciones
Especificaciones
| Antígeno | RIP2 |
| Aplicaciones | ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot |
| Clasificación | Monoclonal |
| Clon | AF28D3 |
| Conjugado | Unconjugated |
| Formulación | HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide |
| génica | RIPK2 |
| N.º de referencia del gen | O43353, P58801 |
| Alias de gen | CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; RIP-2 |
| Símbolos de los genes | RIPK2 |
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Título del producto
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