Progesterone Receptor, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Human PgR exists in two forms: 116kDa (B-form) and 81kDa (A-form). Null mutation in PgR gene leads to pleiotrophic reproductive abnormalities. Expression of PgR has been suggested to predict better clinical response to endocrine therapy than ER alone. PgR is phosphorylated on multiple serine residues (at least seven sites) through distinct groups of sites coordinately regulated by hormone and different kinases.