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Phospho-IRF3 (Ser385) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA538285
Detalles adicionales : Peso : 0.10000kg
Descripción
IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKK epsilon and TBK1. IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These events likely play a role in activation of IRF-3.Especificaciones
Phospho-IRF3 (Ser385) | |
Polyclonal | |
Unconjugated | |
IRF3 | |
IRF3, IRF-3, IRF3, Interferon regulatory factor 3 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
292892, 3661, 54131 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q14653, P70671 | |
IRF3 | |
A synthetic phosphopeptide derived from human IRF-3 around the phosphorylation site of Ser385 (G-A-SP-S-L) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |