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p53 Mouse, Unlabeled, Clone: 80, BD

Mouse Monoclonal Antibody

499.27€

Especificaciones

Antígeno p53
Clon 80
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 1
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15895309
Ver documentos Detalles de la promoción
BD Biosciences
610184
150 μg Este artículo actualmente no está disponible o ha sido discontinuado.
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Descripción

Descripción

The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene is associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20 bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase. It is thought that MDM2 is a feedback regulator of p53. In addition, a p53-inducible gene, Cip1, has been identified and shown to suppress tumor cell growth in culture.

Especificaciones

Especificaciones

p53
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2b κ
Affinity Purified
80
Western Blot
Unconjugated
RUO
Canine, Human
IgG2a, κ
Primary
Store undiluted at -20°C.
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For Research Use Only.