Invitrogen™ NF-H Monoclonal Antibody (RNF 402)

Descripción

OMA1-06116 detects both the phosphorylated and non-phosphorylated forms of the 200 kDa neurofilament from rat, guinea pig, rabbit, dog, hamster, chicken, mouse, cow, monkey, sheep, xenopus and human tissues. OMA1-06116 has been successfully used in immunohistochemical (frozen & paraffin) and Western blot procedures. By Western blot, this antibody detects a single ~200 kDa protein representing both forms of the 200 kDa neurofilament from rat brain homogenate. OMA1-06116 antigen is cytoskeletal preparation of calf brain tissue.

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).