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MRP-1 Mouse anti-Human, FITC, Clone: QCRL-3, BD
Descripción
Reacts with an intracellular epitope of the multidrug resistance protein (MRP1). MRP1 is a 190kDa integral membrane phosphoglycoprotein, member of the ATP-binding cassette transporter proteins, overexpressed in some drug-selected resistant cell lines and has been shown to cause multidrug resistance in transfected cells. Clone QCRL-3 was generated using non-denatured membranes from H69AR, an MRP1-overexpressing, multidrug resistant, drug-selected cell line. Its epitope has been localized to the first nucleotide binding domain of MRP1 between amino acids 617 and 932.3 QCRL-3 does not cross-react with human MDR1 or MDR3 gene products, nor with murine MRP1. It is reported that mAb QCRL-3 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles.
Host Species: Mouse
Clone: QCRL-3
Isotype: IgG2a, κ
Cross Reactivity: Human
Flow Cytometry
Especificaciones
Especificaciones
| Antígeno | MRP-1 |
| Aplicaciones | Flow Cytometry |
| Clasificación | Monoclonal |
| Clon | QCRL-3 |
| Conjugado | FITC |
| Formulación | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| Especie del huésped | Mouse |
| Método de purificación | Affinity Purified |
| Cantidad | 100 Tests |
| Estado normativo | RUO |
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For Research Use Only.
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