MMP3 Monoclonal Antibody, Clone: SPM293, Invitrogen™

Descripción

MMP3 Antibody (SPM293), MA1-21234, from Invitrogen. Species Reactivity: Human; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG2b
Clone: SPM293
Immunogen: APMA (4-Aminophenylmercuric acetate) activated Human stromelysin-1 (SL-1).
Formulation: 250μL purified antibody (0.2mg/mL) in PBS with 1% BSA and sodium azide; pH 7.4
Synonyms: CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1
Uniprot Accession: P08254
Entrez GeneID: 4314
Gene Symbol: MMP3
MA1-21234 detects MMP-3 in human samples. MA1-21234 has been successfully used in immunofluorescence, immunohistochemistry (Paraffin) and Western blot procedures. Suggested positive controls include conditioned, serum-free medium from TPA treated human endometrial cells, placenta, bladder, breast, and ovarian carcinomas. MA1-21234 immunogen is APMA (4-Aminophenylmercuric acetate) activated human stromelysin-1 (SL-1).